منابع مشابه
Muscular Dystrophy—Reason for Optimism?
Characterization of the mechanisms underlying various types of muscular dystrophy has been an outstanding triumph of molecular biology. Increasing clarification of the aberrant cellular processes responsible for these conditions may ultimately permit the development of effective means for molecular intervention, allowing correction of the abnormal cellular physiology that results in the dystrop...
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Heart transplants are now an established mode of treatment for heart failure in adults. Are they justified in children? We believe they are. The aim is to provide a normal quality of life. However, for some, particularly those with an acute cardiomyopathy, it can be a question of life or death. Long term survival is limited by the development of coronary artery disease (probably as a result of ...
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There is no doubt that, in infectious disease, genetic predisposition plays a very important role in clinical outcome. Sepsis is a polygenic syndrome initiated by infection. A fact confounding the situation is that two factors--the macroorganism and the microorganism--are at play at the same time; hence of genotype effect must be assessed in light of their interaction. From a phylogenetic point...
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Over the last several years proteins involved in base excision repair (BER) have been implicated in active DNA demethylation. We review the literature supporting BER as a means of active DNA demethylation, and explain how the various components function and cooperate to remove the potentially most enduring means of epigenetic gene regulation. Recent evidence indicates that the same pathways imp...
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Modern concurrent programming benefits from a large variety of synchronization techniques. These include conventional pessimistic locking, as well as optimistic techniques based on conditional synchronization primitives or transactional memory. Yet, it is unclear which of these approaches better leverage the concurrency inherent to multi-cores. In this paper, we compare the level of concurrency...
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ژورنال
عنوان ژورنال: BMJ
سال: 2008
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.39465.484421.3a